Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung

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• 作者：Verena Lammel^a ; Christina Stoeckle^b ; Barbara Padberg^c ; Roland Zweifel^d ; Dirk L. Kienle^a ; Walter H. Reinhart^a ; Hans-Uwe Simon^b ; ^{hus@pki.unibe.ch}
• 关键词：Eosinophilia ; GM-CSF ; Lung cancer ; Large-cell carcinoma ; GM-CSF receptor ; Thromboembolism
• 刊名：Lung Cancer
• 出版年：2012
• 期刊代码：187_01695002
• 类别：med
• 出版时间：June, 2012
• 卷：76
• 期：3
• 页码：493-495
• 文件大小：428 K

摘要

In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.