A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel
- 作者：MaLing Gou ; XingYi Li ; Mei Dai ; ChangYang Gong ; XianHuo Wang ; Yao Xie ; HongXin Deng ; LiJuan Chen ; Xia Zhao ; ZhiYong Qian ; YuQuan Wei
- 关键词：Drug delivery system ; Nanoparticles ; Pluronic F127 ; Hydrophobic drug ; Poly(
//www.sciencedirect.com/scidirimg/entities/25b.gif" alt="var epsilon" title="var epsilon" border="0">-caprolactone)-poly(ethylene glycol)-poly(
- 刊名：International Journal of Pharmaceutics
- 出版年：2008
- 期刊代码：24_03785173
- 类别：pha
- 出版时间：9 July 2008
- 卷：359
- 期：1-2
- 页码：228-233
- 文件大小：696 K
摘要
In this article, a novel local hydrophobic drug delivery system: nanoparticles in thermo-sensitive hydrogel, was demonstrated. First, honokiol, as a model hydrophobic drug, loaded poly(
-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCEC) nanoparticles were prepared by emulsion solvent evaporation method, and then were incorporated into thermo-sensitive F127 hydrous matrix. The obtained injectable hydrophobic drug delivery system can act as a depot for sustained release of honokiol in situ. The lower critical solution temperature (LCST) of the composite matrix increases with increase in the mass of incorporated nanoparticles, or with decrease in the amount of residual organic solvent in the system. Honokiol release profile in vitro was studied, and the results showed that honokiol could be sustained released from the system. The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol.
-caprolactone)-poly(ethylene glycol)-poly(-caprolactone) (PCEC) nanoparticles were prepared by emulsion solvent evaporation method, and then were incorporated into thermo-sensitive F127 hydrous matrix. The obtained injectable hydrophobic drug delivery system can act as a depot for sustained release of honokiol in situ. The lower critical solution temperature (LCST) of the composite matrix increases with increase in the mass of incorporated nanoparticles, or with decrease in the amount of residual organic solvent in the system. Honokiol release profile in vitro was studied, and the results showed that honokiol could be sustained released from the system. The described injectable drug delivery system might have great potential application for local delivery of hydrophobic drugs such as honokiol.