• 作者：A. Rodrí ; guez^a ; ^{ahr1161@yahoo.es} ; L. Socí ; as^b ; J.E. Guerrero^c ; J.C. Figueira^d ; N. Gonzá ; lez^e ; E. Maraví ; -Poma^f ; L. Lorente^g ; M. Martí ; n^h ; A. Albaya-Morenoⁱ ; A. Algora-Weber^j ; J. Vallé ; s^k ; C. Leó ; n-Gil^l ; T. Lisboa^m ; C. Balasiniⁿ ; M. Villabó ; n^o ; R. Pé ; rez-Padilla^p ; D. Barahona^q ; J. Rello^a ; Grupo Españ ; ol de Trabajo de Gripe A Grave/Sociedad Españ ; ola de Medicina Intensiva ; Cr&iacute ; tica y Unidades Coronarias^&diams ;
• 关键词：Gripe A(H1N1)v ; Nueva pandemia gripe A ; Iberoam&eacute ; rica ; S&iacute ; ndrome de distr&eacute ; s respiratorio agudo
• 刊名：Medicina Intensiva
• 出版年：2010
• 期刊代码：pca255_02105691
• 类别：med
• 出版时间：March 2010
• 卷：34
• 期：2
• 页码：87-94
• 文件大小：178 K

ass="h4">Introduction

Pandemic Influenza A (H1N1)v infection is the first pandemic in which intensive care units (ICU) play a fundamental role. It has spread very rapidly since the first cases were diagnosed in Mexico with the subsequent spread of the virus throughout the Southern Cone and Europe during the summer season.

ass="h4">Objective

This study has aimed to compare the clinical presentation and outcome among the critical patients admitted to the ICU until July 31, 2009 in Spain with some series from Latin America.

ass="h4">Material and method

Six series of critically ill patients admitted to the ICU were considered. Clinical characteristics, complications and outcome were compared between series.

ass="h4">Results

Young patients (35鈥?5 years) with viral pneumonia as a predominant ICU admission cause with severe respiratory failure and a high need of mechanical ventilation (60鈥?00%) were affected. Obesity, pregnancy and chronic lung disease were risk factors associated with a worse outcome, however there was a high number of patients without comorbidities (40鈥?0%). Mortality rate was between 25鈥?0%and higher in the Latin America series, demonstrating the specific potential pathogenesis of the new virus. The use of antiviral treatment was delayed (between 3 and 6 days) and not generalized, with greater delay in Latin America in regards to Spain.

ass="h4">Conclusions

These data suggest that a more aggressive treatment strategy, with earlier and easier access to the antiviral treatment might reduce the number of ICU admissions and mortality.