SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress

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• 作者：Patrizia D'Aquila ; Giuseppina Rose ; Maria Luisa Panno ; Giuseppe Passarino ; Dina Bellizzi ; ^{dina.bellizzi@unical.it}
• 关键词：ATP ; Adenosine triphosphate ; FOXO ; Forkhead box O ; GAPDH ; Glyceraldehyde-3-phosphate dehydrogenase ; GPX1 ; Glutathione peroxidase 1 ; GSR ; Glutathione reductase ; NAD+/NADH ; Nicotinamide adenine dinucleotide ; ND5 ; NADH dehydrogenase 5 ; OXPHOS ; Oxidative phos
• 刊名：Gene
• 出版年：2012
• 期刊代码：73_03781119
• 类别：bio
• 出版时间：15 April, 2012
• 卷：497
• 期：2
• 页码：323-329
• 文件大小：360 K

摘要

Signaling pathways between mitochondrial and nuclear genomes are activated to preserve cellular homeostasis, especially in the event of stress. Using cybrid cell lines, we investigated whether inherited mitochondrial DNA (mtDNA) variants modulate the expression profiles of mammalian sirtuins (SIRT1-7) under oxidative stress conditions. We found that the expression of the SIRT3 gene was down-regulated in cybrids harboring mtDNA of the J haplogroup, which correlated with mitochondrial function, resulting in a decline of NAD⁺/NADH and ATP levels. Overall, the data reported here highlight a link between SIRT3, mitochondrial DNA variability and mitochondrial functionality, three fundamental components of the cellular stress response.