Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer

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• 作者：Ying Liu^a ; ^b ; Liang-Zhi Xu^b ; ^{licw555@yahoo.com.cn} ; ^{ly9587@yahoo.com.cn}
• 关键词：GSTM1 ; Polymorphism ; Cervical cancer ; Meta-analysis
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2012
• 期刊代码：pca68_19957645
• 类别：med
• 出版时间：June, 2012
• 卷：5
• 期：6
• 页码：480-484
• 文件大小：277 K

摘要

Objective

To investigate association between glutathione S-transferases (GSTs) and cervical cancer.

Methods

Published literature from PubMed, EMBASE, and other databases were retrieved. All studies evaluating the association between GSTM1/GSTT1 polymorphisms and cervical were included. Pooled odds ratio (OR) and 95%confidence interval (CI) were calculated using fixed- or random-effects model.

Results

A total of 15 case-control studies were included in the meta-analysis of GSTM1 genotypes (1鈥?25 cases and 2鈥?04 controls). The overall result showed that the association between GSTM1 null genotype and risk for cervical cancer was statistically significant (OR=1.53, 95%CI=1.18-2.00). Great heterogeneity was found between studies. Subgroup analysises were performed based on smoking and ethnicity. Our results showed that smokers with null GSTM1 genotype had higher risk of cervical cancer (OR=1.56, 95%CI=1.01-2.41). For the ethnicity stratification, significant increased risk of null GSTM1 genotype was found in Chinese and Indian population, but no increased risk in other population.

Conclusions

This meta-analysis provides strong evidence that the GSTM1 null genotype is associated with the development of cervical cancer, and especially in Chinese and Indian population, and smoking shows a modification on the association between GSTM1 null genotype and cervical cancer.