Optimization of a biocatalytic single-step alkene cleavage of aryl alkenes

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• 作者：Harald Mang ; Johannes Gross ; Miguel Lara ; Christian Goessler ; Hans E. Schoemaker ; Georg M. Guebitz ; Wolfgang Kroutil
• 刊名：Tetrahedron
• 出版年：2007
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：16 April 2007
• 卷：63
• 期：16
• 页码：3350-3354
• 文件大小：255 K

摘要

The oxidative cleavage of a CC double bond adjacent to an aryl moiety was achieved in the presence of a protein preparation of Trametes hirsuta G FCC 047 to yield the corresponding aldehydes. Molecular oxygen was the only oxidant required. All positive substrates had a CC bond conjugated to an aromatic system, all other compounds tested not fulfilling this requirement were non-substrates. The optimum reaction conditions are 20 °C, pH 6–6.5, 15%v/v ethanol as co-solvent at an apparent oxygen pressure of 2 bar.