Gut-liver axis: The impact of gut microbiota on non alcoholic fatty liver disease

详细信息	查看全文 | 推荐本文 |

• 作者：D. Compare^a ; P. Coccoli^a ; A. Rocco^a ; O.M. Nardone^a ; S. De Maria^b ; M. Cartenì ; ^b ; G. Nardone^a ; ^{nardone@unina.it}
• 关键词：Gut microbiota ; Bacterial translocation ; Endotoxemia ; Non alcoholic fatty liver disease ; Probiotics
• 刊名：Nutrition ; Metabolism and Cardiovascular Diseases
• 出版年：2012
• 期刊代码：233_09394753
• 类别：med
• 出版时间：June, 2012
• 卷：22
• 期：6
• 页码：471-476
• 文件大小：214 K

摘要

Aim

To examine the impact of gut microbiota on non alcoholic fatty liver disease (NAFLD) pathogenesis.

Data synthesis

Emerging evidence suggests a strong interaction between gut microbiota and liver. Receiving approximately 70%of its blood supply from the intestine, the liver represents the first line of defence against gut-derived antigens. Intestinal bacteria play a key role in the maintenance of gut-liver axis health. Disturbances in the homeostasis between bacteria- and host-derived signals at the epithelial level lead to a break in intestinal barrier function and may foster 鈥渂acterial translocation鈥? defined as the migration of bacteria or bacterial products from the intestinal lumen to mesenteric lymph nodes or other extraintestinal organs and sites. While the full repertoire of gut-derived microbial products that reach the liver in health and disease has yet to be explored, the levels of bacterial lipopolysaccharide, a component of the outer membrane of Gram-negative bacteria, are increased in the portal and/or systemic circulation in several types of chronic liver diseases. Derangement of the gut flora, particularly small intestinal bacterial overgrowth, occurs in a large percentage (20-75%) of patients with chronic liver disease. In addition, evidence implicating the gut-liver axis in the pathogenesis of metabolic liver disorders has accumulated over the past ten years.

Conclusions

Complex metabolic diseases are the product of multiple perturbations under the influence of triggering factors such as gut microbiota and diet, thus, modulation of the gut microbiota may represent a new way to treat or prevent NAFLD.