Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain
- 作者：Gye Sun Jeon ; Sang-Ha Park ; Kuem-Ju Lee ; Min-Soo Lee ; Boe-Gwun Chun and Kyung-Ho Shin
- 关键词：BDNF (brain-derived neurotrophic factor) ; MK801 ; Valproate ; Retrosplenial cortex
- 刊名：European Journal of Pharmacology
- 出版年：2006
- 期刊代码：24_00142999
- 类别：neu
- 出版时间：18 September 2006
- 卷：545
- 期：2-3
- 页码：142-146
- 文件大小：562 K
摘要
To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.