Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma

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• 作者：Tiina-Liisa Erkinheimo ; Anna Sivula ; Heini Lassus ; Mira Heinonen ; Henry Furneaux ; Caj Haglund ; Ralf Butzow and Ari Ristimä ; ki
• 关键词：HuR ; COX-2 ; Inhibin-α ; Ovarian cancer ; Mucinous
• 刊名：Gynecologic Oncology
• 出版年：2005
• 期刊代码：295_00908258
• 类别：med
• 出版时间：2005
• 卷：99
• 期：1
• 页码：14-19
• 文件大小：194 K

摘要

Cyclooxygenase-2 (COX-2) expression has been found to associate with poor prognosis in several types of carcinomas. HuR is an mRNA stability protein and it regulates the expression of COX-2.

Objectives and methods.

We analyzed the expression of COX-2 and HuR in 64 mucinous ovarian carcinoma specimens by immunohistochemistry.

Results.

In mucinous tumors, high COX-2 protein expression was found in epithelial cancer cells in 39%(22/56) and in stromal cells in 24%(13/55) of the specimens. The expression of COX-2 in cancer cells correlated with high grade (P = 0.0285), but stromal COX-2 expression had no correlation with any clinical parameter tested. Cytoplasmic HuR protein expression was observed in cancer cells in 47%(27/57) and in stromal cells in 7%(4/56) of the mucinous tumors, and it correlated with COX-2 expression in the cancer cells (P = 0.0162) but not in the stroma.

Conclusion.

Our results support the hypothesis that cytoplasmic HuR is connected to COX-2 expression in ovarian carcinoma, but that its role is restricted to the transformed epithelial cancer cells.