An efficient and convenient formal synthesis of Jaspine B from d-xylose

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• 作者：Ming-Li Zhao ; En Zhang ; Jie Gao ; Zhao Zhang ; Yu-Tao Zhao ; Wen Qu ; Hong-Min Liu ; ^{liuhm@zzu.edu.cn}
• 关键词：Jaspine B ; d-Xylose ; Formal synthesis
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：1 April, 2012
• 卷：351
• 期：Complete
• 页码：126-129
• 文件大小：377 K

摘要

A formal synthesis of Jaspine B was completed in 42.4%overall yield with only three purification steps (one by crystallization and two by column chromatography). The key step in the synthesis involves a regio- and stereoselective epoxide ring-opening reaction and the configuration inversion of the C3-hydroxyl group through oxidation and reduction. All of the reagents and materials used were quite common and inexpensive.