Reverse gyrase: An insight into the role of DNA-topoisomerases
- 作者：Marc Nadal
- 关键词：Reverse gyrase ; DNA topology ; Topoisomerase ; Hyperthermophile
- 刊名：Biochimie
- 出版年：2007
- 期刊代码：24_03009084
- 类别：bio
- 出版时间：April 2007
- 卷：89
- 期：4
- 页码：447-455
- 文件大小：218 K
摘要
Reverse gyrase was discovered more than twenty years ago. Recent biochemical and structural results have greatly enhanced our understanding of their positive supercoiling mechanism. In addition to new biochemical properties, a fine tuning of reverse gyrase regulation in response to DNA damaging agents has been recently described. These data give us a new insight in the cellular role of reverse gyrase. Moreover, it has been proposed that reverse gyrase has been implicated in genome stability.