Low dose dual-source CT angiography in infants with complex congenital heart disease: A randomized study

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• 作者：Yang Gao^a ; ^{gaoyang226@126.com} ; Bin Lu^a ; ^{blu@vip.sina.com} ; Zhihui Hou^a ; ^{konglingyihui@126.com} ; Fangfang Yu^a ; ^{yufangfang8653@163.com} ; Huili Cao^a ; ^{xdzhang7946@yahoo.com.cn} ; Lei Han^a ; ^{hanlei_301@163.com} ; Runze Wu^b ; ^{runze.wu@siemens.com}
• 关键词：Complex congenital heart disease ; Prospective ECG-triggering ; Dual-source CT angiography ; Radiation dose ; Image quality
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：July, 2012
• 卷：81
• 期：7
• 页码：e789-e795
• 文件大小：911 K

摘要

Objectives

To investigate the radiation dose and image quality of prospective ECG-triggering dual-source CT angiography in infants with complex congenital heart disease (CHD) in comparison with retrospective ECG-gated scanning.

Methods

Ninety-six infants less than 1 year old (60/36 male/female, age: 4.8 卤 2.7 months, weight: 5.8 卤 1.8 kg) with complex CHD were enrolled. Three image acquisition protocols were set: group 1: 80 kV, 100 mA, retrospective ECG-gated protocol; group 2: 80 kV, 100 mA, prospective ECG-triggering protocol with acquisition window of 380 ms; group 3: 80 kV, 100 mA, prospective ECG-triggering protocol with acquisition window of 200 ms. Patients were selected to any one of the protocols randomly. The signal-to-noise ratios (SNR) were calculated in the ascending aorta and the pulmonary artery trunk. Image quality was assessed by a five-point score. A score of <3 represents non-diagnostic. Effective radiation dose (ED) was calculated.

Results

Image quality score of groups 1, 2 and 3 were 4.1 卤 0.4, 4.0 卤 0.6 and 4.2 卤 0.6 (p = 0.224). SNR of ascending aorta and pulmonary artery trunk among them had no statistical difference (all p > 0.05). The average ED (median) of groups 1, 2 and 3 were 1.17 卤 0.07 mSv (1.25 mSv), 0.72 卤 0.24 mSv (0.78 mSv) and 0.48 卤 0.41 mSv (0.39 mSv). Any two of the three groups had significant differences (all p < 0.001).

Conclusion

Prospective ECG-triggering DSCT angiography associated with a significantly lower ED than retrospective protocol, while maintaining image quality for diagnosis. Prospective ECG-triggering DSCT angiography could be used as a very important second-line diagnostic tool in infants with complex CHD.