TGF尾1 SNPs and radio-induced toxicity in prostate cancer patients

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• 作者：Laura Fachal^a ; Antonio Gó ; mez-Caamañ ; o^b ; Manuel Sá ; nchez-Garc&iacute ; a^c ; Ana Carballo^b ; Paula Peleteiro^b ; Ramó ; n Lobato-Busto^c ; Á ; ngel Carracedo^a ; Ana Vega^a ; ^{ana.vega@usc.es}
• 关键词：TGF尾1 ; Radiotherapy ; Toxicity ; Prostate cancer ; Polymorphism ; SNP
• 刊名：Radiotherapy and Oncology
• 出版年：2012
• 期刊代码：231_01678140
• 类别：med
• 出版时间：May, 2012
• 卷：103
• 期：2
• 页码：206-209
• 文件大小：164 K

摘要

Background and purpose

We have performed a case-control study in 413 prostate cancer patients to test for association between TGF尾1 and the development of late normal-tissue toxicity among prostate cancer patients treated with three-dimensional conformational radiotherapy (3D-CRT)

Materials and methods

Late gastrointestinal and genitourinary toxicities were assessed for at least two years after radiotherapy in 413 patients according to CTCAEvs3 scores. Codominant genotypic tests and haplotypic analyses were undertaken to evaluate the correlation between TGF尾1 SNPs rs1800469, rs1800470 and rs1800472 and radio-induced toxicity.

Results

Neither the SNPs nor the haplotypes were found to be associated with the risk of late toxicity.

Conclusions

We were able to exclude up to a 2-fold increase in the risk of developing late gastrointestinal and genitourinary radio-induced toxicity due to the TGF尾1 SNPs rs1800469 and rs1800470, as well as the two most frequent TGF尾1 haplotypes.