• 作者：Isabel Orea Soler^a ; ^{isabelorea@gmail.com} ; Fá ; tima Illá ; n Gó ; mez^a ; Manuel Gonzá ; lvez Ortega^b ; M. Soledad Alcaraz Tafalla^a ; Matí ; as Pé ; rez Paredes^b ; M. Luisa Lozano Almela^c ; M. Herminia Pascual Saura^a ; Mercedes Pascual Dí ; az^a
• 关键词：Prote&iacute ; na C reactiva ; Molé ; culas solubles de adhesió ; n intercelular tipo 1 ; Cirug&iacute ; a bariá ; trica ; Obesidad
• 刊名：Endocrinolog铆a y Nutrici贸n
• 出版年：2010
• 期刊代码：pca151_15750922
• 类别：med
• 出版时间：March 2010
• 卷：57
• 期：3
• 页码：90-94
• 文件大小：157 K

Background and objectives

Obesity is associated with a state of chronic low-grade inflammation. A causal association between inflammatory processes and atherogenesis has been proposed. The aim of this study was to evaluate changes in the proinflammatory profile of morbidly obese patients who underwent bariatric surgery. Serum C-reactive protein (CRP) and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations were measured before and after massive weight loss due to gastric bypass.

Methods

In this prospective study we measured CRP and sICAM-1 concentrations in 50 morbidly obese patients (19 men and 31women) at baseline and 3, 6 and 12 months after gastric bypass.

Results

Body mass index (BMI), CRP, and sICAM-1 decreased significantly. BMI correlated with CRP but not with sICAM-1.

Conclusions

The improvement in vascular risk profile after weight loss in morbidly obese patients could be partially explained by changes in inflammatory status.