Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma

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• 作者：Qingna Zhai^a ; ^b ; Liang Zhou^c ; Chunjuan Zhao^a ; ^b ; Jun Wan^d ; Zhendong Yu^a ; ^{zhendongyu66@hotmail.com} ; Xin Guo^c ; Jie Qin^c ; Jing Chen^c ; Ruijing Lu^a ; ^b
• 关键词：Renal cell carcinoma ; MicroRNA ; miR-508-3p ; miR-509-3p
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：23 March, 2012
• 卷：419
• 期：4
• 页码：621-626
• 文件大小：631 K

摘要

MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.