Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes

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• 作者：Monisha Banerjee ; ¹ ; ^{mhglucknow@yahoo.com} ; ^{banerjee_monisha30@rediffmail.com} ; Madhukar Saxena¹
• 关键词：Cytokines ; IL-1 family ; IL-1 gene polymorphisms ; Mode of action ; Type 2 Diabetes
• 刊名：Clinica Chimica Acta
• 出版年：2012
• 期刊代码：54_00098981
• 类别：med
• 出版时间：16 August, 2012
• 卷：413
• 期：15-16
• 页码：1163-1170
• 文件大小：454 K

摘要

Cytokines are small cell signaling protein molecules which encompass a large and diverse family. They consist of immunomodulating agents such as interleukins and inteferons. Virtually all nucleated cells, especially endo/epithelial cells and macrophages are potent producers of IL-1, IL-6 and TNF-伪. IL-1 family is a group of cytokines which play a central role in the regulation of immune and inflammatory responses. Type 2 diabetes (T2D) has been recognized as an immune mediated disease leading to impaired insulin signaling and selective destruction of insulin producing 尾-cells in which cytokines play an important role. Disturbance of anti-inflammatory response could be a critical component of the chronic inflammation resulting in T2D. IL-1 family of cytokines has important roles in endocrinology and in the regulation of responses associated with inflammatory stress. The IL-1 family consists of two pro-inflammatory cytokines, IL-1伪 and IL-1尾, and a naturally occurring anti-inflammatory agent, the IL-1 receptor antagonist (IL-1Ra or IL-1RN). This review is an insight into the different types of cytokines belonging to IL-1 family, their modes of action and association with Type 2 diabetes.