• 作者：Francesc Alameda^a ; ^{86780@imas.imim.es} ; Gemma Mancebo^b ; Sergi Mojal^c ; Lara Pijuan^a ; Belé ; n Lloveras^a ; Emilia Romero^a ; Inmaculada Soler^a ; Mercè ; Bosch^a ; Amparo Quiñ ; onero^a ; Fernando Larrazabal^b ; Ramó ; n Carreras^b ; Sergi Serrano^a
• 关键词：LSIL ; Persistencia ; Progresió ; n ; Seguimiento ; Carga viral
• 刊名：Revista Espa帽ola de Patolog铆a
• 出版年：2011
• 期刊代码：pca318_16998855
• 类别：med
• 出版时间：July-September 2011
• 卷：44
• 期：3
• 页码：139-144
• 文件大小：147 K

Objective

To study the HPV viral load (VL) in the prediction of the persistence and/or progression in LSIL cases.

Study design

Prospective study. 102 consecutive cases diagnosed as LSIL in 2006 with follow-ups at 6, 12 and 24 months subsequent to diagnosis.

Method

Liquid based cytology (ThinPrep^庐, Hologic, Malborough, MA, USA), for the cytological study. Hybrid Captute II Test (HCII-HR, Quiagen, Hilden, Germany), for the determination of the presence or absence of High-Risk HPV.

Results

87 of the 102 cases studied were HR-HPV positive (85.3%). The presence or progression was detected in 54%, 42%and 33.35%of the cases in the first, second and third controls respectively. No lesion was demonstrated in 46%, 57%and 66.7%of the cases at first, second and third controls respectively. 19 cases progressed to HSIL; 11 of which were detected on the first control, 6 on the second and 2 on the third. The sensitivity of the VL for detecting HSIL never exceeded 89%, with a specificity always inferior to 40%.

Conclusion

The VL determined by the HC2 method is not a useful indicator of prognosis in the follow-up of LSIL cases.