Carbamazepine Inhibits the Potentiation by Adenosine Analogues of Agonist Induced Inositolphosphate Formation in Hippocampal Astrocyte Cultures

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• 作者：Biber ; Knut ; Walden ; Jö ; rg ; Gebicke-Hä ; rter ; Peter ; Berger ; Mathias ; van Calker ; Dietrich
• 关键词：Carbamazepine ; lithium ; inositolphosphate-calcium-signalling ; affective disorders ; adenosine A₁-receptors ; astrocytes
• 刊名：Biological Psychiatry
• 出版年：1996
• 期刊代码：34_00063223
• 类别：med
• 出版时间：October 1, 1996
• 卷：40
• 期：7
• 页码：563-567
• 文件大小：336 K

摘要

Carbamazepine (CBZ) resembles lithium in its beneficial effects in therapy and prophylaxis of affective disorders. Since lithium is presumed to act via an attenuation of the inositolphosphate/Ca²⁺-second messenger system, it is of particular interest whether or not CBZ might also have inhibitory effects on this type of signal transduction. CBZ is an antagonist of adenosine A₁-receptor subtypes. We show here that activation of adenosine A₁-receptors potentiates the phenylephrine induced formation of inositolphosphates in hippocampal astrocytes and that this potentiating effect is inhibited by CBZ at a therapeutically relevant concentration. These results indicate that CBZ can by antagonism of adenosine A₁-receptors inhibit the inositolphosphate/Ca²⁺-signalling in neural pathways regulated by adenosine.