Investigation of vascular invasion and genetic polymorphisms of DPD IVS14+1 G>A, UGT1A1 3156 G>A, and UGT1A1 28 tandem repeats in colorectal cancer patients in Taiwan

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• 作者：Ming-Yii Huang^a ; ^b ; ^c ; ^&dagger ; ; Meng-Lin Huang^d ; ^&dagger ; ; Jaw-Yuan Wang^b ; ^e ; ^f ; ^g ; ^{cy614112@ms14.hinet.net} ; Shiu-Ru Lin^h ; ⁱ ; ^{srlin@ms2.hinet.net}
• 关键词：colorectal cancer ; DPD ; genetic polymorphism ; UGT1A1 ; vascular invasion
• 刊名：Genomic Medicine ; Biomarkers ; and Health Sciences
• 出版年：2012
• 期刊代码：pca172_22114254
• 类别：med
• 出版时间：March-June, 2012
• 卷：4
• 期：1-2
• 页码：28-29
• 文件大小：164 K

摘要

In the present study, multiple chemotherapeutic agent-related genetic polymorphisms, including dihydropyrimidine dehydrogenase (DPD) IVS14+1 G>A, UGT1A1 3156 G>A, and UDP-glucuronosyltransferase (UGT)1A1 28 tandem repeats, were analyzed in patients with colorectal cancer and studied in correlation with the clinical features of those patients. The genotypes from 273 patients with stages I-IV colorectal cancer who underwent operations were determined by means of polymerase chain reaction-restriction fragment length polymorphism. The results showed that the genotype distribution of DPD GG, UGT1A1 3156 GG, and UGT1A1 28 tandem repeats 5/6 or 6/6 in Taiwanese subjects were 98.4%, 82.2%, and 80.6%, respectively. After analysis of the relationship between the genotypes and clinicopathological data of the patients, a significant correlation was observed between vascular invasion in patients with genetic polymorphisms ofDPDGG, UGT1A13156GG, and UGT1A1 28 repeat 5/6 or 6/6 (OR: 2.236, p聽=聽0.015). There was a statistical correlation between vascular invasion and tumor invasion, lymph node metastasis, cancer stage, differentiation, perineural invasion, and survival (all p聽<聽0.05). The results of the present study highly suggest that DPDGG, UGT1A13156GG, and UGT1A1 28 repeat 5/6 or 6/6 genotypes and vascular invasion could be prognostic factors for Taiwanese patients with colorectal cancer.