- 作者：Keiichiro Ishibashi ; k_ishi@saitama-med.ac.jp ; Kensuke Kumamoto ; Kouki Kuwabara ; Naoko Hokama ; Toru Ishiguro ; Tomonori Ohsawa ; Norimichi Okada ; Tatsuya Miyazaki ; Masaru Yokoyama ; Yoshitaka Tsuji ; Norihiro Haga ; Hideyuki Ishida
- 关键词：bowel preparation ; colon cancer ; sennoside ; surgical site infection
- 刊名：Asian Journal of Surgery
- 出版年：2012
- 期刊代码：24_10159584
- 类别：med
- 出版时间：April, 2012
- 卷：35
- 期：2
- 页码：81-87
- 文件大小：188 K
Summary
Objective
We retrospectively evaluated the usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery.Methods
A total of 86 patients were given 12 mg of sennoside on the evening prior to resective surgery for colon cancer, followed by intravenous antimicrobial prophylaxis used on the day of surgery or until postoperative day 2.
Results
The incidence of surgical site infection in the study group was 4.7%, which was comparable to that in the historical control patients (3.5%, p > 0.99), who had received polyethylene glycol for mechanical bowel preparation prior to colon surgery. On multivariate logistic regression analysis, only body mass index (p = 0.04) was an independent significant factor affecting the surgical site infection. The intraoperative spillage was not influenced by the presence of stenosis, although the amount of fecal matter was higher in the upstream colon segment (p < 0.01) and downstream segment (p = 0.07) in patients with a stenotic lesion occupying more than two-thirds of the lumen (n = 29) than in those without such severe stenosis (n = 57).
Conclusion
Sennoside seems to be an acceptable agent for mechanical bowel preparation even in patients with stenosis.