Contents of issue
- 关键词：Paraneoplastic neurological syndromes ; Ri antibody ; Cerebrospinal fluid ; Oligoclonal bands
- 刊名：Journal of Food Composition and Analysis
- 出版年：2008
- 期刊代码：119_08891575
- 类别：abs
- 出版时间：May 2008
- 卷：21
- 期：3
- 页码：i
- 文件大小：104 K
摘要
The presence of Ri-specific oligoclonal IgG bands in the CSF was investigated in five patients with paraneoplastic anti-Ri associated neurological syndromes (PNS) and six controls. In 4/5 CSF samples reactivity of IgG bands with recombinant Ri antigen was found using isoelectrofocusing combined with affinity blotting; in one patient with absence of oligoclonal bands of total IgG in CSF Ri-specific oligoclonal bands were detected with the same sample, indicating a higher sensitivity of Ri-specific affinity blotting as compared to affinity blotting with anti-human IgG antibodies. Our results confirm previous studies demonstrating IgG synthesis against onconeuronal antigens by intrathecal B-cell clones in PNS and extend this observation to patients with anti-Ri syndrome. The pathogenic relevance of these antibodies, however, is further challenged by the finding that specific intrathecal IgG synthesis might not be a prerequisite of CNS involvement, because it was missed in one of our patients.