Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation
- 作者：Goulder ; Philip J.R. ; Pasquier ; Christophe ; Holmes ; Eddie C. ; Liang ; Bin ; Tang ; Yanhua ; Izopet ; Jacques ; et. al.
- 关键词：Vertical transmission ; Escape ; CTL ; Phylogenetic tree ; Gag mutations
- 刊名：Immunology Letters
- 出版年：2001
- 期刊代码：115_01652478
- 类别：med
- 出版时间：November 1, 2001
- 卷：79
- 期：1-2
- 页码：109-116
- 文件大小：438 K
摘要
Cytotoxic T lymphocytes (CTL) play a central role in containment of HIV infection. Evasion of the immune response by CTL escape is associated with progression to disease. It is therefore hypothesised that transmitted viruses encode escape mutations within epitopes that are required for successful control of viraemia. In order to test this hypothesis, escape through the dominant HLA-A2-restricted CTL epitope SLYNTVATL (p17 Gag residues 77–85 SL9) in the setting of mother-to-child-transmission (MTCT) was investigated. Initial data from two families in which the HIV-infected mother expressed HLA-A*0201 and had transmitted the virus to other family members were consistent with this hypothesis. In addition, analysis of the gag sequence phylogeny in one family demonstrated that CTL escape variants can be successfully transmitted both horizontally and vertically. To test the hypothesis further, a larger cohort of transmitting mothers (n