- 作者：Chuan-Hai Zhang ; M.D. ; Ph.D.&lowast ; ; &dagger ; ; Ge-Liang Xu ; B.S.&dagger ; ; geliangxu2010@163.com ; Wei-Dong Jia ; M.D. ; Ph.D.&dagger ; ; Jian-Sheng Li ; B.S.&dagger ; ; Jin-Liang Ma ; M.S.&dagger ; ; Wei-Hua Ren ; Ph.D.&dagger ; ; Yong-Sheng Ge ; M.D. ; Ph.D.&dagger ; ; Ji-Hai Yu ; M.S.&dagger ; ; Wen-Bin Liu ; M.D.&dagger ; ; Wei Wang ; M.S.&dagger ;
- 关键词：signal transducer and activator of transcription 3 ; Twist ; E-cadherin ; prognosis ; hepatocellular carcinoma
- 刊名：Journal of Surgical Research
- 出版年：2012
- 期刊代码：299_00224804
- 类别：med
- 出版时间：1 May, 2012
- 卷：174
- 期：1
- 页码：120-129
- 文件大小：1246 K
Background
To examine the expression of signal transducer and activator of transcription 3 (STAT3) and its activated form (p-STAT3), Twist, and E-cadherin in hepatocellular carcinoma (HCC), and聽explore聽their correlations with HCC progression and prognosis.Materials and Methods
The expression profiles of STAT3, p-STAT3, Twist, and E-cadherin were assessed on 100 clinical HCC samples and 10 normal liver tissues聽by using an immunohistochemical staining method,聽and their correlations with clinicopathologic parameters and survival of HCC patients were statistically analyzed.
Results
The results demonstrated that the positive rate of STAT3, p-STAT3, and Twist in HCC was significantly higher than that in normal liver tissues; furthermore, 52%of HCC lesions showed reduced E-cadherin expression. Correlation analysis indicated that p-STAT3 was positively correlated with Twist expression, whereas Twist was negatively correlated with E-cadherin expression; p-STAT3, Twist, or E-cadherin expression was significantly associated with HCC invasion and metastasis. Survival analysis showed that HCC patients with p-STAT3, Twist positive expression, or reduced E-cadherin expression had a significantly shorter survival duration than those with p-STAT3, Twist negative expression, or those with normal E-cadherin expression. Multivariate analysis identified p-STAT3, Twist, or E-cadherin expression as an independent prognostic factor for overall survival of HCC patients聽after surgery.
Conclusions
By this study, we suggest that activated STAT3 signal may associate with Twist and E-cadherin expression and mediate HCC invasiveness and metastasis; abnormal p-STAT3/Twist/E-cadherin signal axis may predict poor prognosis of HCC patients.