Prevalence, Morbidity, and Mortality of Heart Failure-Related Hospitalizations in Children in the United States: A Population-Based Study

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• 作者：Joseph W. Rossano ; MD¹ ; ^{rossanoj@email.chop.edu} ; Jeffrey J. Kim ; MD² ; Jamie A. Decker ; MD² ; Jack F. Price ; MD² ; Farhan Zafar ; MD³ ; Daniel E. Graves ; PhD⁴ ; David L.S. Morales ; MD³ ; Jeffrey S. Heinle ; MD³ ; Biykem Bozkurt ; MD⁵ ; Jeffrey A. Towbin ; MD⁶ ; Susan W. Denfield ; MD² ; William J. Dreyer ; MD² ; John L. Jefferies ; MD⁶
• 关键词：Heart failure ; pediatrics ; epidemiology
• 刊名：Journal of Cardiac Failure
• 出版年：2012
• 期刊代码：162_10719164
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：6
• 页码：459-470
• 文件大小：530 K

摘要

Background

Few data exist on prevalence, morbidity, and mortality of pediatric heart failure hospitalizations. We tested the hypotheses that pediatric heart failure-related hospitalizations increased over time but that mortality decreased. Factors associated with mortality and length of stay were also assessed.

Methods and Results

A retrospective analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Database was performed for pediatric (age 鈮?8 years) heart failure-related hospitalizations for the years 1997, 2000, 2003, and 2006. Hospitalizations did not significantly increase over time, ranging from 11,153 (95%confidence interval [CI] 8,898-13,409) in 2003 to 13,892 (95%CI 11,528-16,256) in 2006. Hospital length of stay increased from 1997 (mean 13.8 days, 95%CI 12.5-15.2) to 2006 (mean 19.4 days, 95%CI 18.2 to 20.6). Hospital mortality was 7.3%(95%CI 6.9-8.0) and did not vary significantly between years; however, risk-adjusted mortality was less in 2006 (odds ratio 0.70, 95%CI 0.61 to 0.80). The greatest risk of mortality occurred with extracorporeal membrane oxygenation, acute renal failure, and sepsis.

Conclusions

Heart failure-related hospitalizations occur in 11,000-14,000 children annually in the United States, with an overall mortality of 7%. Many comorbid conditions influenced hospital mortality.