Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment

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• 作者：Gema Flores^a ; ^b ; Keyvan Dastmalchi^a ; Sturlainny Paulino^a ; Kathleen Whalen^a ; ^c ; Abdoulaye J. Dabo^c ; Kurt A. Reynertson^a ; ¹ ; Robert F. Foronjy^c ; Jeanine M. D&rsquo ; Armiento^c ; Edward J. Kennelly^a ; ^{Edward.kennelly@lehman.cuny.edu}
• 关键词：Eugenia brasiliensis ; Myrtaceae ; Anthocyanins ; Cyanidin ; Delphinidin ; IL-8 ; COPD
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：1 October, 2012
• 卷：134
• 期：3
• 页码：1256-1262
• 文件大小：473 K

摘要

Nine anthocyanins (dFont">1-dFont">9) from the edible fruits of Eugenia brasiliensis were identified by HPLC-PDA and LC-MS, and seven of these are described for the first time in this Brazilian fruit. Two of the major anthocyanins, delphinidin (dFont">8) and cyanidin (dFont">9), were studied for their inhibitory activity against chemokine interleukin-8 (IL-8) production before and after cigarette smoke extract (CSE) treatment of cells. In non-treated cells the amount of IL-8 was unchanged following treatment with cyanidin and delphinidin in concentrations 0.1-10 渭M. Both delphinidin (dFont">8) and cyanidin (dFont">9) decreased the production of IL-8 in treated cells, at 1 and 10 渭M, respectively. Delphinidin (dFont">8) demonstrated IL-8 inhibition in the CSE treated cells in a dose-dependent manner.