Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα

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• 作者：Bettina Kö ; nig ; Alex ; er Koch ; Karen Giggel ; Batsuch Dordschbal ; Klaus Eder ; Gabriele I. Stangl
• 关键词：Monocarboxylate transporter 1 ; Peroxisome proliferator-activated receptor (PPAR)-rc="http ; //www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> ; PPARrc="http ; //www.scie
• 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
• 出版年：2008
• 期刊代码：16_03044165
• 类别：bio
• 出版时间：June 2008
• 卷：1780
• 期：6
• 页码：899-904
• 文件大小：541 K

摘要

Peroxisome proliferator-activated receptor (PPAR)-rc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> mediates an adaptive response to fasting by up-regulation of genes involved in fatty acid oxidation and ketone body synthesis. Ketone bodies are transferred in and out of cells by monocarboxylate transporter (MCT)-1. In this study we observed for the first time that activation of PPARrc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> in rats by clofibrate treatment or fasting increased hepatic mRNA concentration of MCT1. In Fao rat hepatoma cells, incubation with the PPARrc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> agonist WY 14,643 increased mRNA concentration of MCT1 whereas the PPARγ agonist troglitazone did not. To elucidate whether up-regulation of MCT1 is indeed mediated by PPARrc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> we treated wild-type and PPARrc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-null mice with WY 14,643. In wild-type mice, treatment with WY 14,643 increased mRNA concentrations of MCT1 in liver, kidney and small intestine whereas no up-regulation was observed in PPARrc="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">-null mice.