Tissue Factor and Atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF

详细信息	查看全文 | 推荐本文 |

• 作者：Marina Camera^a ; ^b ; ^{Marina.Camera@ccfm.it} ; ^{Marina.Camera@unimi.it} ; Marta Brambilla^a ; Laura Facchinetti^a ; Paola Canzano^a ; Rita Spirito^a ; Laura Rossetti^a ; Claudio Saccu^a ; Matteo Nicola Dario Di Minno^c ; Elena Tremoli^a ; ^b
• 关键词：Tissue Factor ; atherosclerosis ; platelets
• 刊名：Thrombosis Research
• 出版年：2012
• 期刊代码：247_00493848
• 类别：med
• 出版时间：March, 2012
• 卷：129
• 期：3
• 页码：279-284
• 文件大小：622 K

摘要

In the last ten years the contribution of both vessel wall-derived tissue factor (TF) and platelets to atherosclerosis has been revisited. At the beginning of the 2000 a circulating blood-borne TF has been proposed to sustain coagulation activation and propagation on the edge of a growing thrombus.

Concomitantly with the observation that platelets not only contribute to thrombus formation, but also take part to the onset of the atherosclerotic lesion, evidences have been provided that they express functionally active TF, making them able to trigger the coagulation cascade.