Intracranial hypertension and cryptococcal meningitis in a girl with AIDS
- 作者：Laverda ; Anna Maria ; Ruga ; Ezia ; Pagliaro ; Alessandra ; Pinello ; Maria Luisa ; Giaquinto ; Carlo
- 关键词：Intracranial hypertension ; Cryptococcal meningitis ; Pediatric AIDS
- 刊名：Brain and Development
- 出版年：1996
- 期刊代码：40_03877604
- 类别：med
- 出版时间：July 8, 1996
- 卷：18
- 期：4
- 页码：330-331
- 文件大小：213 K
摘要
A girl with HIV infection acquired at birth by blood transfusion, was admitted at the age of 10 years for diplopia, vomiting, headache and papilledema. CT scan was negative. A lumbar puncture revealed clear CSF, protein 0.40 g/l, glucose 2 mmol/1, 5 mononuclear cells/mm3. The Indian ink preparation and the latex agglutination antigen test were positive for Cryptococcus n. Treatment with amphotericin B and flucytosine was started. After 10 days, since the in vitro susceptibility testing of the isolates showed resistence to both drugs, fluconazolo (400 mg/day) was started. Acetazolamide, furosemide and spironolactone were then added to the antifungal therapy for the persistence of severe intracranial hypertension. Diuretics were maintained for 10 weeks. The patient returned to school two and half months after the admission to the hospital. After 19 months, she is doing well and she is on maintenance of fluconazole (200 mg/day). We hypothesized that the increased intracranial pressure would be due to an impaired CSF reabsorption probably as a consequence of a direct cryptococcal infiltration of the villi.