VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells

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• 作者：Zhitao Zhou^a ; Xiao Lu^a ; Ping Zhu^a ; Wei Zhu^b ; Xia Mu^c ; Rongmei Qu^a ; Ming Li^a ; ^{limimg2010@yahoo.cn}
• 关键词：VCC-1 ; VEGF-correlated chemokine 1 ; HCC ; hepatocellular carcinoma ; CXCL17 ; chemokine (C-X-C motif) ligand 17
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：6 April, 2012
• 卷：420
• 期：2
• 页码：336-342
• 文件大小：1318 K

摘要

Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a recently described chemokine, is hypothesized to be associated with carcinogenesis. However, the molecular mechanisms by which aberrant VCC-1 expression determines poor outcomes of cancers are unknown. In this study, we found that VCC-1 was highly expressed in hepatocellular carcinoma (HCC) tissue. It was also associated with proliferation of HepG2 cells, and inhibition of cisplatin-induced apoptosis of HepG2 cells. Conversely, down-regulation of VCC-1 in HepG2 cells increased cisplatin-induced apoptosis of HepG2 cells. In summary, these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy.