Dietary 伪-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis

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• 作者：Ayman Ibrahim ; M.D. ; Ph.D.^a ; Moutaz Aziz ; M.D.^b ; Aktham Hassan ; M.D. ; Ph.D.^a ; Khaly Mbodji ; Ph.D.^a ; Elodie Collasse ; B.Sc.^b ; Moï ; se Coë ; ffier ; Ph.D.^a ; ^c ; Fré ; dé ; ric Bounoure ; Pharm.D.^d ; Guillaume Savoye ; M.D. ; Ph.D.^a ; ^e ; Pierre Dé ; chelotte ; M.D. ; Ph.D.^a ; ^c ; Rachel Marion-Letellier ; Ph.D.^a ; ^{marion_rachel@hotmail.com}
• 关键词：伪-Linolenic acid ; Colitis ; Heme oxygenase-1 ; Intestine ; 蠅-3 Polyunsaturated acids ; Adhesion molecules
• 刊名：Nutrition
• 出版年：2012
• 期刊代码：81_08999007
• 类别：abs
• 出版时间：July-August, 2012
• 卷：28
• 期：7-8
• 页码：799-802
• 文件大小：674 K

摘要

Objective

The 蠅-3 polyunsaturated fatty acid therapy in inflammatory bowel disease is focused on the effects on fish oil-derived polyunsaturated fatty acids. We speculated that a vegetal oil rich in 伪-linolenic acid (ALA) might also inhibit colitis. Therefore, we evaluated whether dietary ALA would decrease the expression of adhesion molecules by inducing the protective enzyme heme oxygenase-1 (HO-1) in a rat colitis model.

Methods

Colitis was induced at day 0 by an intrarectal injection of 2-4-6-trinitrobenzen sulfonic acid (TNBS), whereas control rats received the vehicle. Rats were fed an ALA-rich formula 450 mg 路 kg^鈭? 路 d^鈭?, whereas the other colitic group (TNBS) and the control group were fed an isocaloric corn oil formula for 14 d (from day 鈭? to day 7). The colonic expressions of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor A receptor-2 (VEGFR2), and HO-1 were studied by immunohistochemistry.

Results

The ALA-rich diet significantly decreased the expression of ICAM-1, VCAM-1, and VEGFR-2 compared the TNBS group, but it did not affect the expression of HO-1.

Conclusion

A vegetal ALA-rich formula decreases the expression of ICAM-1, VCAM-1, and VEGFR-2 and independently of HO-1 in rats with TNBS-induced colitis. Further studies are required to evaluate its therapeutic potential in inflammatory bowel disease as an alternative to fish oil.