Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes

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• 作者：Remko S. Kuipers^a ; ^{remkokuipers@hotmail.com} ; Martine F. Luxwolda^a ; Pieter J. Offringa^b ; E. Rudy Boersma^c ; D.A. Janneke Dijck-Brouwer^a ; Frits A.J. Muskiet^a
• 关键词：AA ; arachidonic acid ; DHA ; docosahexaenoic acid ; GA ; gestational age ; FA ; fatty acid ; LA ; linoleic acid ; LCP ; long-chain polyunsaturated saturated fatty acids ; MCSAFA ; medium-chain saturated fatty acids (> ; 14 ; 0) ; MUFA ; monounsaturated fatty acids ; OMP
• 刊名：Prostaglandins ; Leukotrienes and Essential Fatty Acids (PLEFA)
• 出版年：2012
• 期刊代码：32_09523278
• 类别：bio
• 出版时间：April-May, 2012
• 卷：86
• 期：4-5
• 页码：189-199
• 文件大小：882 K

摘要

Introduction

There are no data on the intrauterine fatty acid (FA) compositions of brain, liver and adipose tissue of infants born to women with high fish intakes.

Subjects and methods

We analyzed the brain (n=18), liver (n=14) and adipose tissue (n=11) FA compositions of 20 stillborn infants with different gestational ages (range 8-38 weeks) born to Tanzanian women with low linoleic acid (LA) intakes and high intakes of docosahexaenoic (DHA) and arachidonic (AA) acids from local fish.

Results and discussion

With advancing gestation, brain saturated-FA (SAFA; in g/100 g FA), polyunsaturated-FA (PUFA), DHA, 20:3蠅6, 22:4蠅6 and 22:5蠅6 increased, while monounsaturated-FA (MUFA), 20:3蠅9, 22:3蠅9 and AA decreased. Decreasing brain AA might be caused by increasing AA-metabolism to 20:3蠅6, 22:4蠅6 and 22:5蠅6. In the liver, SAFA, PUFA and LA increased, while MUFA decreased with gestation. The steep increase of (mostly de novo synthesized) SAFA in adipose tissue coincided with relative decreases of MUFA, PUFA, DHA, LA and AA with advancing gestation. Compared to Western infants, the currently studied African infants had higher DHA, lower AA, and a higher DHA/AA-ratio in brain and adipose tissue, while the LA content of adipose tissue was lower.

Conclusion

The low LA and high DHA and AA intakes by the mothers of these infants might support optimal 伪-linolenic (ALA) vs. LA competition for 螖5D and 螖6D-activities and DHA vs. AA antagonism. Conversely, the Western diet, characterized by high LA and lower DHA and AA intakes, might disturb these evolutionary conserved mechanisms aiming at an optimal 蠅3/蠅6-balance.