Cytotoxic cardenolides from the stems of Periploca forrestii

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• 作者：Yong Li ; Yun-Bao Liu ; Shi-Shan Yu ; ^{yushishan@imm.ac.cn} ; Xiao-Guang Chen ; Xian-Fu Wu ; Shuang-Gang Ma ; Jing Qu ; You-Cai Hu ; Jing Liu ; Hai-Ning Lv
• 关键词：Periploca forrestii ; Cardenolides ; Cytotoxic activity
• 刊名：Steroids
• 出版年：2012
• 期刊代码：142_0039128x
• 类别：bio
• 出版时间：April, 2012
• 卷：77
• 期：5
• 页码：375-381
• 文件大小：386 K

摘要

Six new cardenolides, periforosides D-E (1-2), periforgenin C (3) and periforosides F-H (4-6), as well as 10 previously identified cardenolides (7-16) were isolated from the ethanol extract of the stems of Periploca forrestii. The structures of the new compounds were determined using extensive spectroscopic analyses including HRESI-MS, 1D and 2D NMR data. Evaluation of the cytotoxic activity of all the isolated compounds in five different human cancer cell lines indicated that compounds 2-6, 8, 9 and 12-16 have potent activity.