PTX cruiser: driving autoimmunity via TLR4

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• 作者：Racke ; Michael K. ; Hu ; Wei ; Lovett-Racke ; Amy E.
• 刊名：Trends in Immunology
• 出版年：2005
• 期刊代码：257_14714906
• 类别：med
• 出版时间：June, 2005
• 卷：26
• 期：6
• 页码：289-291
• 文件大小：3.43 M

摘要

Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.