Obesity but not overweight increases the incidence and mortality of leukemia in adults: A meta-analysis of prospective cohort studies

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• 作者：Jorge J. Castillo^a ; ^{jcastillo@lifespan.org} ; John L. Reagan^a ; Randall R. Ingham^b ; Michael Furman^b ; Samir Dalia^b ; Basma Merhi^b ; Saed Nemr^b ; Ali Zarrabi^c ; Joanna Mitri^d
• 关键词：Obesity ; Body mass index ; Leukemia ; Meta-analysis ; Incidence ; Mortality ; Risk
• 刊名：Leukemia Research
• 出版年：2012
• 期刊代码：186_01452126
• 类别：med
• 出版时间：July, 2012
• 卷：36
• 期：7
• 页码：868-875
• 文件大小：938 K

摘要

The main objectives of the present meta-analysis of prospective cohort studies were to evaluate the role of obesity on the incidence and mortality of leukemia in adults. Obesity was associated with a relative risk (RR) of 1.26 (95%CI 1.17-1.37; p < 0.001) for leukemia incidence and 1.29 (95%CI 1.11-1.49; p = 0.001) for mortality. Obesity was also associated with an increased incidence of acute myeloid leukemia (RR 1.53, 95%CI 1.26-1.85; p < 0.001), chronic lymphocytic leukemia (RR 1.17, 95%CI 1.08-1.27; p < 0.001), chronic myeloid leukemia (RR 1.16, 95%CI 1.04-1.30; p = 0.007) and acute lymphoblastic leukemia (RR 1.62, 95%CI 1.12-2.32; p = 0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men.