- 作者：John K. Chan ; Alessandra Magistris ; Vera Loizzi ; Fritz Lin ; Joanne Rutgers ; Kathryn Osann ; Philip J. DiSaia and Michael Samoszuk
- 刊名：Gynecologic Oncology
- 出版年：2005
- 期刊代码：295_00908258
- 类别：med
- 出版时间：2005
- 卷：99
- 期：1
- 页码：20-25
- 文件大小：220 K
lass="h4">Objective.To determine clinical or biological associations between mast cell density, blood clotting, angiogenesis, and survival of patients with advanced ovarian cancer.lass="h4">Methods.
Tumor tissue sections were assessed for mast cell density by staining for mast cell tryptase, blood clotting by staining of thrombosed blood vessels, and angiogenesis by CD34 expression. Chi-square, Kaplan–Meier, and Cox proportional hazard statistical analyses were used.
lass="h4">Results.
44 women with stage III–IV ovarian cancers had tumor blocks available for immunohistochemical analysis. Higher mean vessel density (MVD) (>11 vessels/400× field) predicted for better survival than lower MVD (≤11 vessels/400× field) (P = 0.004). Women whose tumors had low levels of peri-tumoral mast cell infiltration had a mean survival of 40.6 months compared to 50.6 months in those whose tumors had high levels (P = 0.47). Tumors with higher MVD and high peri-tumoral mast cell infiltration had a mean survival of 80.3 months compared to 37.8 months in those with low mast cell density or low MVD (P = 0.015). Patients with tumors showing a low degree of blood clotting had a mean survival of 45.5 compared to 45.1 months in those with tumors showing a high degree of blood clotting (P = 0.91). There was no significant association between angiogenesis and mast cell density (P = 0.123). In multivariate analysis, higher MVD remained as a significant prognostic factor for improved survival after adjusting for clotting and mast cell density.
lass="h4">Conclusions.
Our data suggest that peri-tumoral mast cell infiltration in tumors with high MVD predicts for improved survival in women with advanced epithelial ovarian cancer.