An approach to an enantioselective synthesis of crisamicin A via a novel double Hauser–Kraus annulation strategy

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• 作者：Olivier Andrey ; Jonathan Sperry ; Uffe S. Larsen ; Margaret A. Brimble
• 关键词：Pyranonaphthoquinone antibiotics ; Crisamicin A ; Hauser– ; Kraus annulation
• 刊名：Tetrahedron
• 出版年：2008
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：28 April 2008
• 卷：64
• 期：18
• 页码：3912-3927
• 文件大小：595 K

摘要

A double Hauser–Kraus annulation between biscyanophthalide 4 and the d-mannose derived enone 39 provides access to an advanced intermediate 54 that is an excellent scaffold to effect an enantioselective total synthesis of crisamicin A 1.