Glucose-monitoring neurons in the mediodorsal prefrontal cortex
- 作者：Bernadett Nagy ; bernadett.nagy@aok.pte.hu ; Istvá ; n Szabó ; Szilá ; rd Papp ; Gá ; bor Taká ; cs ; Csaba Szalay ; Zoltá ; n Kará ; di
- 关键词：AMY ; amygdala ; DA ; dopamine ; GM ; glucose-monitoring ; GR ; glucose-receptor ; GS ; glucose-sensitive ; LHA ; lateral hypothalamic area ; MB ; methylene-blue ; mdPFC ; mediodorsal prefrontal cortex ; NAcc ; nucleus accumbens ; NTS ; nucleus of the solitary tract ; OBF ; o
- 刊名：Brain Research
- 出版年：2012
- 期刊代码：8_00068993
- 类别：neu
- 出版时间：20 March, 2012
- 卷：1444
- 期：Complete
- 页码：38-44
- 文件大小：778 K
摘要
The mediodorsal prefrontal cortex (mdPFC), a key structure of the limbic neural circuitry, plays important roles in the central regulation of feeding. As an integrant part of the forebrain dopamine (DA) system, it performs complex roles via interconnections with various brain areas where glucose-monitoring (GM) neurons have been identified. The main goal of the present experiments was to examine whether similar GM neurons exist in the mediodorsal prefrontal cortex. To search for such chemosensory cells here, and to estimate their involvement in the DA circuitry, extracellular single neuron activity of the mediodorsal prefrontal cortex of anesthetized Wistar and Sprague-Dawley rats was recorded by means of tungsten wire multibarreled glass microelectrodes during microelectrophoretic administration of d-glucose and DA. One fourth of the neurons tested changed in firing rate in response to glucose, thus, proved to be elements of the forebrain GM neural network. DA responsive neurons in the mdPFC were found to represent similar proportion of all cells; the glucose-excited units were shown to display excitatory whereas the glucose-inhibited neurons were demonstrated to exert mainly inhibitory responses to dopamine. The glucose-monitoring neurons of the mdPFC and their distinct DA sensitivity are suggested to be of particular significance in adaptive processes of the central feeding control.