Mitochondrial bioenergetic function and metabolic plasticity in stem cell differentiation and cellular reprogramming

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• 作者：Chien-Tsun Chen^a ; Shu-Han Hsu^a ; Yau-Huei Wei^a ; ^b ; ^{joeman@ym.edu.tw}
• 关键词：bFGF ; basic fibroblast growth factor ; Pol 纬 ; DNA polymerase 纬 ; ESC ; embryonic stem cell ; HIF ; hypoxia-inducible factor ; HSC ; hematopoietic stem cell ; iPSC ; induced pluripotent stem cell ; MSC ; mesenchymal stem cell ; mtDNA ; mitochondrial DNA ; mTOR ; mammal
• 刊名：Biochimica et Biophysica Acta (BBA)/General Subjects
• 出版年：2012
• 期刊代码：16_03044165
• 类别：bio
• 出版时间：May, 2012
• 卷：1820
• 期：5
• 页码：571-576
• 文件大小：503 K

摘要

Background

The self-renewal ability and pluripotent differentiation potential of stem cells hold great promise for regenerative medicine. Many studies focus on the lineage-specific differentiation and expansion of stem cells, but little is known about the regulation of glycolysis and mitochondrial biogenesis and function during these processes. Recent studies have demonstrated a strong correlation between cellular metabolism and the pluripotency and differentiation potential of stem cells, which indicates the importance of bioenergetic function in the regulation of stem cell physiology.

Scope of review

We summarize recent findings in the control of stem cell competence through the regulation of bioenergetic function in embryonic, hematopoietic, mesenchymal, and induced pluripotent stem cells, and discuss the up-to-date understanding of the molecular mechanisms involved in these biological processes.

Major conclusions

It is believed that the metabolic signatures are highly correlated with the stemness status (high glycolytic flux) and differentiation potential (mitochondrial function) of stem cells. Besides, mitochondrial rejuvenation has been observed to participate in the reprogramming process.

General significance

Understanding the metabolic regulation of stem cells will have great value in the characterization and isolation of stem cells with better differentiation potential. It also provides novel strategies of metabolic manipulation to increase the efficiency of cellular reprogramming. This article is part of a Special Issue entitled Biochemistry of Mitochondria, Life and Intervention 2010.