Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus

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• 作者：Seung-Hong Lee^a ; Kwan-Hee Min^b ; Ji-Sook Han^b ; Dae-Ho Lee^c ; Deok-Bae Park^c ; Won-Kyo Jung^d ; Pyo-Jam Park^e ; Byong-Tae Jeon^f ; Se-Kwon Kim^g ; You-Jin Jeon^a ; ^h ; ^{youjinj@jejunu.ac.kr}
• 关键词：IPGTT ; intraperitoneal glucose tolerance test ; GK ; glucokinase ; G6Pase ; glucose-6-phosphatase ; PEPCK ; phosphoenolpyruvate carboxykinase ; SOD ; superoxide dismutase ; CAT ; catalase
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：March-April, 2012
• 卷：50
• 期：3-4
• 页码：575-582
• 文件大小：387 K

摘要

Recently, there has been a growing interest in alternative therapies of marine algae for diabetes. Therefore, the anti-diabetic effects of brown alga, Ecklonia cava was investigated in type 2 diabetic animal. Male C57BL/KsJ-db/db (db/db) mice were divided into control, dieckol rich extract of E. cava (AG-dieckol), or rosiglitazone (RG) groups. The blood glucose, blood glycosylated hemoglobin levels, and plasma insulin levels were significantly lower in the AG-dieckol and RG groups than in the control db/db mice group, while glucose tolerance was significantly improved in the AG-dieckol group. AG-dieckol markedly lowered plasma and hepatic lipids concentration compared to the control db/db mice group. The antioxidant enzyme activities were significantly higher in the AG-dieckol group than in the control db/db mice group, yet its TBARS level was markedly lower compared to the RG group. With regard to hepatic glucose regulating enzyme activities, glucokinase activity was enhanced in the AG-dieckol group mice, while glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities in the AG-dieckol group mice were significantly lowered than those in the control db/db mice group. These results suggest that AG-dieckol exert an anti-diabetic effect in type 2 diabetic mice by improving the glucose and lipid metabolism and antioxidant enzymes.