摘要
Two series of fused tricyclic indoles were identified as potent and selective S1Pb>1b> agonists. In vivo these agonists produced a significant reduction in circulating lymphocytes which translated into robust efficacy in several rodent models of autoimmune disease. Importantly, these agonists were devoid of any activity at the S1Pb>3b> receptor in vitro, and correspondingly did not produce S1Pb>3b> mediated bradycardia in telemeterized rat.