Chlorinated briarane-type diterpenoids from the gorgonian coral Ellisella robusta (Ellisellidae)
- 作者：Ping-Jyun Sung ; Michael Y. Chiang ; Wei-Tse Tsai ; Jui-Hsin Su ; Yu-Mine Su ; Yang-Chang Wu
- 关键词：Briarane ; Robustolide ; Ellisella robusta ; X-ray diffraction
- 刊名：Tetrahedron
- 出版年：2007
- 期刊代码：107_00404020
- 类别：ch
- 出版时间：24 December 2007
- 卷：63
- 期：52
- 页码：12860-12865
- 文件大小：586 K
摘要
Four chlorinated metabolites featuring briarane carbon skeletons have been isolated from the gorgonian coral Ellisella robusta, which was collected off the coast of southern Taiwan: two new natural products, robustolides D (1) and E (2), and two known metabolites, robustolides F (3) and G (4). The structures of metabolites 1–4 were determined by spectroscopic methods, using 1D and 2D NMR in particular. The structures and absolute stereochemistry of robustolides D (1), F (3), and G (4) were directly established by X-ray diffraction analysis. Robustolide D (1) is the first metabolite of briarane-related natural products found to possess two halogen atoms.