When oxygen runs short: the microenvironment drives host-pathogen interactions

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• 作者：Inga Dietz^a ; Stefan Jerchel^a ; Má ; rta Szaszá ; k^a ; Kensuke Shima^a ; Jan Rupp^a ; ^b ; ^{jan.rupp@uk-sh.de}
• 关键词：Hypoxia ; Host&ndash ; pathogen interactions ; Hypoxia-inducible factor-1
• 刊名：Microbes and Infection
• 出版年：2012
• 期刊代码：65_12864579
• 类别：imm
• 出版时间：April, 2012
• 卷：14
• 期：4
• 页码：311-316
• 文件大小：254 K

摘要

Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.