Paradoxical reduction of atherosclerosis in apoE-deficient mice with obesity-related type 2 diabetes

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• 作者：Lyngdorf ; L.G. ; Gregersen ; S. ; Daugherty ; A. ; Falk ; E.
• 关键词：Atherosclerosis ; Type 2 diabetes ; Obesity ; Insulin resistance ; Gold thioglucose ; Food restriction ; Apolipoprotein E deficient mice
• 刊名：Cardiovascular Research
• 出版年：2003
• 期刊代码：48_00086363
• 类别：med
• 出版时间：October 1, 2003
• 卷：59
• 期：4
• 页码：854-862
• 文件大小：568 K

摘要

Objective: The effect of obesity and insulin resistance on the development of atherosclerosis was evaluated in apoE-deficient (ApoE^{−/−}) mice. A previously described obesity model, in which the hypothalamic satiety center can be destroyed by a single gold thioglucose (GTG) injection, was used. To evaluate the effect of starvation on atherosclerosis ApoE^{−/−} mice were food-restricted with 25%less chow than ad libitum-fed control mice. Methods: Sixty-eight ApoE^{−/−} mice were allocated into a control group (n