MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions

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• 作者：Juliane Lescher^a ; Franziska Paap^a ; Verena Schultz^a ; Laura Redenbach^a ; Uta Scheidt^a ; Hendrik Rosewich^b ; Stefan Nessler^a ; Eberhard Fuchs^c ; Jutta Gä ; rtner^b ; Wolfgang Brü ; ck^a ; Andreas Junker^a ; ^{junker@med.uni-goettingen.de}
• 关键词：MicroRNA ; Multiple sclerosis ; EAE ; miRNA-155 ; miRNA-146a/b ; Marmoset
• 刊名：Journal of Neuroimmunology
• 出版年：2012
• 期刊代码：32_01655728
• 类别：neu
• 出版时间：15 May, 2012
• 卷：246
• 期：1-2
• 页码：27-33
• 文件大小：641 K

摘要

Here we demonstrate that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles miRNA regulation in active human MS lesions. Detailed quantitative PCR analyses of the most up- and downregulated miRNAs of active human MS lesions in dissected lesions from marmoset EAE brains and inflamed spinal cords of EAE mice revealed that the conserved and highly regulated miRNAs, miRNA-155, miRNA-142-3p, miRNA-146a, miRNA-146b and miRNA-21, turned out to be similarly upregulated in marmoset and mouse EAE lesions.