Anti-mitotic potential of 7-diethylamino-3(2鈥?benzoxazolyl)-coumarin in 5-fluorouracil-resistant human gastric cancer cell line SNU620/5-FU

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• 作者：Nam Hyun Kim^a ; ¹ ; Su-Nam Kim^b ; ¹ ; Joa Sub Oh^c ; Seokjoon Lee^d ; Yong Kee Kim^e ; ^{yksnbk@sookmyung.ac.kr}
• 关键词：7-Diethylamino-3(2&prime ; -benzoxazolyl)-coumarin ; Microtubule ; Drug resistance ; 5FU
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：24 February, 2012
• 卷：418
• 期：4
• 页码：616-621
• 文件大小：804 K

摘要

In this study, we investigate an anti-mitotic potential of the novel synthetic coumarin-based compound, 7-diethylamino-3(2鈥?benzoxazolyl)-coumarin, in 5-fluorouracil-resistant human gastric cancer cell line SNU-620-5FU and its parental cell SNU-620. It exerts the anti-proliferative effects with similar potencies against both cancer cells, which is mediated by destabilization of microtubules and subsequent mitotic arrest. Furthermore, this compound enhances caspase-dependent apoptotic cell death via decreased expression of anti-apoptotic genes. Taken together, our data strongly support anti-mitotic potential of 7-diethylamino-3(2鈥?benzoxazolyl)-coumarin against drug-resistant cancer cells which will prompt us to further develop as a novel microtubule inhibitor for drug-resistant cancer chemotherapy.