Core-shell Fe₃O₄@NaLuF₄:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging

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• 作者：Xingjun Zhu ; Jing Zhou ; Min Chen ; Mei Shi ; ^{shimei@fudan.edu.cn} ; Wei Feng ; Fuyou Li ; ^{fyli@fudan.edu.cn}
• 关键词：Upconversion luminescence (UCL) ; Upconversion nanophosphors ; Luminescence imaging ; Core&ndash ; shell ; Tri-modality imaging
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：June, 2012
• 卷：33
• 期：18
• 页码：4618-4627
• 文件大小：1851 K

摘要

Core-shell Fe₃O₄@NaLuF₄:Yb,Er/Tm nanostructure (MUCNP) with multifunctional properties has been developed using a step-wise synthetic method. The successful fabrication of MUCNP has been confirmed by transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray analysis and X-ray photoelectron spectroscopy. The MUCNP exhibits superparamagnetic property with saturation magnetization of 15聽emu聽g^鈭?, and T₂-enhanced magnetic resonance (MR) effect with an r₂ value of 21.63聽s^鈭?聽mM^鈭? at 0.5聽T, resulting from the Fe₃O₄ cores. Moreover, the NaLuF₄-based MUCNP provides excellent X-ray attenuation and upconversion luminescence (UCL) emission under excitation at 980聽nm. In聽vivo MR, computed tomography (CT) and UCL images of tumor-bearing mice show that the MUCNP can be successfully used in multimodal imaging. In聽vitro tests reveal that the MUCNP is non-cytotoxic. These results suggest that the developed MUCNP could be served as an MR, CT and UCL probe for tri-modality imaging.