Glucagon-like peptide-1 response to acarbose in elderly type 2 diabetic subjects
- 作者：DeLeon ; Mary Jeanne ; Chandurkar ; Vikram ; Albert ; Stewart G. ; Mooradian ; Arshag D.
- 关键词：Type 2 diabetes ; Alpha-glucosidase inhibitors ; Acarbose ; Aging ; Glucagon-like peptide-1
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2002
- 期刊代码：78_01688227
- 类别：med
- 出版时间：May, 2002
- 卷：56
- 期：2
- 页码：101-106
- 文件大小：158 K
摘要
The anti-hyperglycemic effect of alpha-glucosidase inhibitors (AGI) is partly attributed to their ability to stimulate the secretion of glucagon-like peptide-1 (GLP-1), a gut hormone with insulin stimulating capability. To determine if this mechanism of action contributes significantly to the therapeutic efficacy of AGI in the elderly, 10 type 2 diabetic subjects over the age of 65 years were given a standardized test meal with or without 25, 50, or 100 mg acarbose. The serum glucose, insulin, triglycerides and GLP-1 levels were measured at baseline and at 1 and 2 h postprandially. The anti-hyperglycemic effect of acarbose was maximal at 25-mg dose under these experimental conditions. Serum postprandial insulin and triglycerides levels were not significantly altered with acarbose treatment. The postprandial serum GLP-1 levels rose significantly only in two subjects and only during treatment with 100-mg acarbose. There were no significant correlations between serum GLP-1 and serum glucose or insulin levels. It is concluded that in most elderly type 2 diabetic subjects, maximal anti-hyperglycemic effects can be achieved with relatively small doses of acarbose and that GLP-1 is unlikely to contribute to the clinical efficacy of this agent in this subgroup of subjects.