Induction of type I interferon by high-molecular poly-纬-glutamate protects B6.A2G-Mx1 mice against influenza A virus

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• 作者：Ho-Jin Moon^a ; ¹ ; Jong-Soo Lee^a ; ¹ ; Young-Ki Choi^b ; Jie-Yeun Park^c ; Melbourne R. Talactac^a ; Mohammed Y.E. Chowdhury^a ; Haryoung Poo^d ; Moon-Hee Sung^e ; ^f ; Ji-Hoon Lee^g ; Jae U. Jung^h ; Chul-Joong Kim^a ; ^{cjkim@cnu.ac.kr}
• 关键词：High-molecular-weight poly-纬-glutamate ; Myxovirus resistance protein ; Interferon type I ; B6.A2G-Mx1 mouse ; Influenza A virus
• 刊名：Antiviral Research
• 出版年：2012
• 期刊代码：7_01663542
• 类别：imm
• 出版时间：April, 2012
• 卷：94
• 期：1
• 页码：98-102
• 文件大小：976 K

摘要

In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-纬-glutamate (HM-纬-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-纬-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G-Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-纬-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-纬-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.