The presented study was aimed at verifying the participation of cholinergic pathways (muscarinic and nicotine receptors) in 伪-hederin-induced contraction. The experiments were carried out on rat isolated stomach corpus and fundus strips under isotonic conditions. The preparations were preincubated with either atropine or hexamethonium and then exposed to 伪-hederin. All results are expressed as the percentage of the response to acetylcholine - a reference contractile agent.
The obtained results revealed that the pretreatment of isolated stomach strips (corpus and fundus) with atropine neither prevented nor remarkably reduced the reaction of the preparations to 伪-hederin. Similarly, if the application of saponin was preceded by the administration of hexamethonium, the strength of the contraction of stomach fundus strips induced by 伪-hederin was not modified.
Concluding, it can be assumed that the cholinergic pathways do not participate in 伪-hederin-evoked contraction of rat isolated stomach preparations.
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