• 作者：T. Martí ; nez^a ; ^{mteresa.martinez5@carm.es} ; B. Cordero^a ; S. Medí ; n^b ; A. Sá ; nchez Salmó ; n^c
• 关键词：PET ; Fluoruro s&oacute ; dico ; 18F ; Gammagraf&iacute ; a &oacute ; sea ; 99mTc
• 刊名：Revista Espa帽ola de Medicina Nuclear
• 出版年：2011
• 期刊代码：pca315_02126982
• 类别：med
• 出版时间：November-December 2011
• 卷：30
• 期：6
• 页码：351-353
• 文件大小：126 K

Objective

To establish an automated procedure for the preparation of sodium fluoride ¹⁸F injection using the resources available in our laboratory for the preparation of ¹⁸FDG and to analyze the repercussion of the conditioning column of the fluoride ion entrapment on the characteristics of the final product.

Material and method

The sequence of an ¹⁸FDG synthesis module prepared so that it traps the fluoride ion from the cyclotron in ion-exchange resin diluted with 0.9%sodium chloride. The final solution was dosified and sterilized in a final vial in an automatized dispensing module. Three different column conditioning protocols within the process were tested. Quality controls were run according to USP聽32 and EurPh聽6, adding control of ethanol levels of residual solvent and quality controls of the solution at 8聽h post-preparation.

Results

Activation of the resin cartridges with ethanol and water was the chosen procedure, with fluoride ion trapping >聽95%and pH around聽7. Ethanol levels were <聽5.000聽ppm. Quality controls at 8聽h indicated that the solution was in compliance with the USP聽32 and EurPh聽6 specifications.

Conclusion

This is an easy, low-cost, reliable automated method for sodium fluoride preparation in PET facilities with existing equipment for ¹⁸FDG synthesis and quality control.